A differential inter-symbol interference (ISI) cancellation method for time domain synchronous orthogonal frequency division multiplexing (TDS-OFDM) systems is proposed. The differential output of an OFDM system can greatly reduce the impact of ISI in the frequency domain and it constructs a convolutional structure, thus the Viterbi decoding algorithm can be used to recover the transmitted information from the output signal. Simulation results show the effectiveness of the proposed method.