This paper presents a Pulse-Width Modulation (PWM) pre-emphasis technique which utilizes time-domain information processing to increase the data rate for a given bandwidth of interconnection. The PWM pre-emphasis method does not change the pulse amplitude as for conventional FIR pre-emphasis, but instead exploits timing resolution. This fits well with recent CMOS technology trends toward higher switching speeds and lower supply voltage. We discuss multiple-valued data transmission based on time-domain pre-emphasis techniques in consideration of higher-order channel effects. Also, a new data-dependent adaptive time-domain pre-emphasis technique is proposed to compensate for the data-dependent jitter.