This paper introduces a user study regarding the effects of hand- and ocular-dominances to pointing gestures. The result of this study is applicable for designing new gesture interfaces which are close to a user's cognition, intuitive, and easy to use. The user study investigates the relationship between the participant's dominances and pointing gestures. Four participant groups—right-handed right-eye dominant, right-handed left-eye dominant, left-handed right-eye dominant and left-handed left-eye dominant—were prepared, and participants were asked to point at the targets on a screen by their left and right hands. The pointing errors among the different participant groups are calculated and compared. The result of this user study shows that using dominant eyes produces better results than using non-dominant eyes and the accuracy increases when the targets are located at the same side of dominant eye. Based on these interesting properties, a method to find the dominant eye for pointing gestures is proposed. This method can find the dominant eye of an individual with more than 90% accuracy.