A new dimension-reduced interference suppression scheme is proposed for DS-CDMA systems over multipath channels. The proposed receiver resolves the problems of interference and multipath effects without needing to estimate the channel and training sequences. The minimum mean squared error (MMSE) criterion is used to obtain an algorithm to cancel the interference of each path. The MMSE filter is composed of two stages based on multipath effects. The proposed receiver has low complexity without great degradation of performance compared with the full dimension MMSE receiver with known channel information. Simulation results show that the proposed receiver converges to the optimal value rapidly because of its reduced dimension.