The magnetic field resolution of the tunnel magneto-resistive (TMR) sensors has been improving and it reaches below 1.0 pT/Hz0.5 at low frequency. The real-time measurement of the magnetocardiography (MCG) and the measurement of the magnetoencephalography (MEG) have been demonstrated by developed TMR sensors. Although the MCG and MEG have been applied to diagnosis of diseases, the conventional MCG/MEG system using superconducting quantum interference devices (SQUIDs) cannot measure the signal by touching the body, the body must be fixed, and maintenance costs are huge. The MCG/MEG system with TMR sensors operating at room temperature have the potential to solve these problems. In addition, it has the great advantage that it does not require a special magnetic shielded room. Further developments are expected to progress to maximize these unique features of TMR sensors.