A novel digital redesign methodology based on evolutionary programming (EP) is introduced to find the 'best' digital controller for optimal tracking design of hybrid uncertain multi-input/ multi-output (MIMO) input-delay systems with constraints on states and controls. To deal with these multivariable concurrent specifications and system restrictions, instead of conventional interval methods, the proposed global optimization scheme is able to practically implement optimal digital controller for constrained uncertain hybrid systems with input time delay. Further, an illustrative example is included to demonstrate the efficiency of the proposed method.