In this paper, we present a framework for composing discrete-event simulation models from a large amount of airspace traffic data without using any specific waypoints. The framework consists of two parts. In the first part, abstracted route graphs that indicate representative routes in the airspace are composed. We propose two methods for extracting important routes in the form of graphs based on combination of various technologies such as space partition, trajectory clustering, and skeleton extraction. In the second part, discrete-event simulation models are composed based on statistical information on flight time along each edge of the abstracted route graph. The composed simulation models have intermediate granularity between micro models, such as multi-agent simulation, and macro models, such as queuing models, and therefore they should be classified as mesoscopic models. Finally, we show numerical results to evaluate the accuracy of the simulation model.