This letter deals with our investigations into improving the performance of a wireless uplink system when an orthogonal frequency-division multiple access (OFDMA) is used as an access scheme. To do this, the OFDMA-based uplink system adopts a frequency diversity coupled with a cyclic time shift (CTS) at the transmitter, which is named as the FD-OFDMA system with CTS. It is found that the multi-user FD-OFDMA system equipping with CTS can decrease the probability of destroying the orthogonality among the users and provide the MAI-robust reception without decreasing the bandwidth efficiency of the system.