An Application of the Optimal Control Strategy for Artificial Production of Protein on Messenger RNA

Hirohumi HIRAYAMA; Norio TAKEUCHI; Yuzou FUKUYAMA

An Application of the Optimal Control Strategy for Artificial Production of Protein on Messenger RNA

Hirohumi HIRAYAMA, Norio TAKEUCHI, Yuzou FUKUYAMA

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The regulatory mechanism of protein synthesis on a messenger RNA was analyzed from view point of the optimal control and discussed about availability for artificial production of peptide and protein. The transient movements of a ribozome through a messenger RNA with its production of peptide was based on the theory proposed by Gordon (1968). The optimal state of total process was defined as the state at which the time dependent change of each process of peptide synthesis has been minimized during a given time interval. This biological problem was converted into mathematical one by setting state variables and utilizing the optimal control theory with the help of Hamiltonian function. The first process of transition of a ribozome on a messenger RNA showed the largest change and with progress of state, the magnitude of change of each process decreased and became a simpler pattern. The effect of weighting coefficient relating with individual process was not confined only to its proper process but extended to all other processes. Each process was affected from all other processes. These were manifestations of effective and rational control strategies particularly for regulation of the sequential reaction in peptide synthesis. Such results were originated in the operation of the optimal control. By simulating physiological experimental data, it is possible to predict at what process and at what degree, the synthesis is regulated in order to achieve the optimal synthesis state. By analyzing the optimal synthesis process in combination with physiological experimental data, it would be possible to create artificial peptide and protein.

Publication: IEICE TRANSACTIONS on Fundamentals Vol.E76-A No.12 pp.2076-2081

Publication Date: 1993/12/25

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Type of Manuscript: Special Section LETTER (Special Section of Letters Selected from the 1993 IEICE Fall Conference)

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Hirohumi HIRAYAMA, Norio TAKEUCHI, Yuzou FUKUYAMA, "An Application of the Optimal Control Strategy for Artificial Production of Protein on Messenger RNA" in IEICE TRANSACTIONS on Fundamentals, vol. E76-A, no. 12, pp. 2076-2081, December 1993, doi: .
Abstract: The regulatory mechanism of protein synthesis on a messenger RNA was analyzed from view point of the optimal control and discussed about availability for artificial production of peptide and protein. The transient movements of a ribozome through a messenger RNA with its production of peptide was based on the theory proposed by Gordon (1968). The optimal state of total process was defined as the state at which the time dependent change of each process of peptide synthesis has been minimized during a given time interval. This biological problem was converted into mathematical one by setting state variables and utilizing the optimal control theory with the help of Hamiltonian function. The first process of transition of a ribozome on a messenger RNA showed the largest change and with progress of state, the magnitude of change of each process decreased and became a simpler pattern. The effect of weighting coefficient relating with individual process was not confined only to its proper process but extended to all other processes. Each process was affected from all other processes. These were manifestations of effective and rational control strategies particularly for regulation of the sequential reaction in peptide synthesis. Such results were originated in the operation of the optimal control. By simulating physiological experimental data, it is possible to predict at what process and at what degree, the synthesis is regulated in order to achieve the optimal synthesis state. By analyzing the optimal synthesis process in combination with physiological experimental data, it would be possible to create artificial peptide and protein.
URL: https://globals.ieice.org/en_transactions/fundamentals/10.1587/e76-a_12_2076/_p

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@ARTICLE{e76-a_12_2076,
author={Hirohumi HIRAYAMA, Norio TAKEUCHI, Yuzou FUKUYAMA, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={An Application of the Optimal Control Strategy for Artificial Production of Protein on Messenger RNA},
year={1993},
volume={E76-A},
number={12},
pages={2076-2081},
abstract={The regulatory mechanism of protein synthesis on a messenger RNA was analyzed from view point of the optimal control and discussed about availability for artificial production of peptide and protein. The transient movements of a ribozome through a messenger RNA with its production of peptide was based on the theory proposed by Gordon (1968). The optimal state of total process was defined as the state at which the time dependent change of each process of peptide synthesis has been minimized during a given time interval. This biological problem was converted into mathematical one by setting state variables and utilizing the optimal control theory with the help of Hamiltonian function. The first process of transition of a ribozome on a messenger RNA showed the largest change and with progress of state, the magnitude of change of each process decreased and became a simpler pattern. The effect of weighting coefficient relating with individual process was not confined only to its proper process but extended to all other processes. Each process was affected from all other processes. These were manifestations of effective and rational control strategies particularly for regulation of the sequential reaction in peptide synthesis. Such results were originated in the operation of the optimal control. By simulating physiological experimental data, it is possible to predict at what process and at what degree, the synthesis is regulated in order to achieve the optimal synthesis state. By analyzing the optimal synthesis process in combination with physiological experimental data, it would be possible to create artificial peptide and protein.},
keywords={},
doi={},
ISSN={},
month={December},}

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TY - JOUR
TI - An Application of the Optimal Control Strategy for Artificial Production of Protein on Messenger RNA
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 2076
EP - 2081
AU - Hirohumi HIRAYAMA
AU - Norio TAKEUCHI
AU - Yuzou FUKUYAMA
PY - 1993
DO -
JO - IEICE TRANSACTIONS on Fundamentals
SN -
VL - E76-A
IS - 12
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - December 1993
AB - The regulatory mechanism of protein synthesis on a messenger RNA was analyzed from view point of the optimal control and discussed about availability for artificial production of peptide and protein. The transient movements of a ribozome through a messenger RNA with its production of peptide was based on the theory proposed by Gordon (1968). The optimal state of total process was defined as the state at which the time dependent change of each process of peptide synthesis has been minimized during a given time interval. This biological problem was converted into mathematical one by setting state variables and utilizing the optimal control theory with the help of Hamiltonian function. The first process of transition of a ribozome on a messenger RNA showed the largest change and with progress of state, the magnitude of change of each process decreased and became a simpler pattern. The effect of weighting coefficient relating with individual process was not confined only to its proper process but extended to all other processes. Each process was affected from all other processes. These were manifestations of effective and rational control strategies particularly for regulation of the sequential reaction in peptide synthesis. Such results were originated in the operation of the optimal control. By simulating physiological experimental data, it is possible to predict at what process and at what degree, the synthesis is regulated in order to achieve the optimal synthesis state. By analyzing the optimal synthesis process in combination with physiological experimental data, it would be possible to create artificial peptide and protein.
ER -