Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis

Wenji YANG; Wei HUANG; Shanxue CHEN

doi:10.1587/transinf.2014EDP7104

Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis

Wenji YANG, Wei HUANG, Shanxue CHEN

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Summary :

Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) of scanned patients. ASL can be utilized as an imaging modality to detect Alzheimer's disease (AD), as brain atrophy of AD patients can be revealed by low CBF values in certain brain regions. However, partial volume effects (PVE), which is mainly caused by signal cross-contamination due to voxel heterogeneity and limited spatial resolution of ASL images, often prevents CBF in ASL from being precisely measured. In this study, a novel PVE correction method is proposed based on pixel-wise voxels in ASL images; it can well handle with the existing problems of blurring and loss of brain details in conventional PVE correction methods. Dozens of comparison experiments and statistical analysis also suggest that the proposed method is superior to other PVE correction methods in AD diagnosis based on real patients data.

Publication: IEICE TRANSACTIONS on Information Vol.E97-D No.11 pp.2912-2918

Publication Date: 2014/11/01

Publicized

Online ISSN: 1745-1361

DOI: 10.1587/transinf.2014EDP7104

Type of Manuscript: PAPER

Category: Image Processing and Video Processing

Authors

Wenji YANG
  Yanshan University,Jiangxi Agricultural University
Wei HUANG
  Nanchang University
Shanxue CHEN
  Faculty of Chongqing University of Posts and Telecommunications

Keyword

arterial spin labeling, magnetic resonance imaging, Alzheimer's disease

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Wenji YANG, Wei HUANG, Shanxue CHEN, "Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis" in IEICE TRANSACTIONS on Information, vol. E97-D, no. 11, pp. 2912-2918, November 2014, doi: 10.1587/transinf.2014EDP7104.
Abstract: Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) of scanned patients. ASL can be utilized as an imaging modality to detect Alzheimer's disease (AD), as brain atrophy of AD patients can be revealed by low CBF values in certain brain regions. However, partial volume effects (PVE), which is mainly caused by signal cross-contamination due to voxel heterogeneity and limited spatial resolution of ASL images, often prevents CBF in ASL from being precisely measured. In this study, a novel PVE correction method is proposed based on pixel-wise voxels in ASL images; it can well handle with the existing problems of blurring and loss of brain details in conventional PVE correction methods. Dozens of comparison experiments and statistical analysis also suggest that the proposed method is superior to other PVE correction methods in AD diagnosis based on real patients data.
URL: https://globals.ieice.org/en_transactions/information/10.1587/transinf.2014EDP7104/_p

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@ARTICLE{e97-d_11_2912,
author={Wenji YANG, Wei HUANG, Shanxue CHEN, },
journal={IEICE TRANSACTIONS on Information},
title={Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis},
year={2014},
volume={E97-D},
number={11},
pages={2912-2918},
abstract={Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) of scanned patients. ASL can be utilized as an imaging modality to detect Alzheimer's disease (AD), as brain atrophy of AD patients can be revealed by low CBF values in certain brain regions. However, partial volume effects (PVE), which is mainly caused by signal cross-contamination due to voxel heterogeneity and limited spatial resolution of ASL images, often prevents CBF in ASL from being precisely measured. In this study, a novel PVE correction method is proposed based on pixel-wise voxels in ASL images; it can well handle with the existing problems of blurring and loss of brain details in conventional PVE correction methods. Dozens of comparison experiments and statistical analysis also suggest that the proposed method is superior to other PVE correction methods in AD diagnosis based on real patients data.},
keywords={},
doi={10.1587/transinf.2014EDP7104},
ISSN={1745-1361},
month={November},}

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TY - JOUR
TI - Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis
T2 - IEICE TRANSACTIONS on Information
SP - 2912
EP - 2918
AU - Wenji YANG
AU - Wei HUANG
AU - Shanxue CHEN
PY - 2014
DO - 10.1587/transinf.2014EDP7104
JO - IEICE TRANSACTIONS on Information
SN - 1745-1361
VL - E97-D
IS - 11
JA - IEICE TRANSACTIONS on Information
Y1 - November 2014
AB - Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) of scanned patients. ASL can be utilized as an imaging modality to detect Alzheimer's disease (AD), as brain atrophy of AD patients can be revealed by low CBF values in certain brain regions. However, partial volume effects (PVE), which is mainly caused by signal cross-contamination due to voxel heterogeneity and limited spatial resolution of ASL images, often prevents CBF in ASL from being precisely measured. In this study, a novel PVE correction method is proposed based on pixel-wise voxels in ASL images; it can well handle with the existing problems of blurring and loss of brain details in conventional PVE correction methods. Dozens of comparison experiments and statistical analysis also suggest that the proposed method is superior to other PVE correction methods in AD diagnosis based on real patients data.
ER -