Eigen-beamforming (EB) transmission for multiple-input multiple-output (MIMO) systems is an effective means to maximize the receiver signal-to-noise ratio (SNR) in a noise-limited environment, but suffers a performance degradation when strong interference signals exist. In this letter, we propose an interference cancellation method for EB signals by constructing a new receive beamforming vector which jointly utilizes the EB matrix and minimum mean-square error (MMSE) spatial demultiplexing. The proposed method is shown to outperform the conventional EB receiver in the entire cell range, with a significant increase in the effective signal-to-interference plus noise ratio (SINR) near the cell boundary.