Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device

Keiji ENPUKU; Yuki SUGIMOTO; Yuya TAMAI; Akira TSUKAMOTO; Takako MIZOGUCHI; Akihiko KANDORI; Naoki USUKI; Hisao KANZAKI; Kohji YOSHINAGA; Yoshinori SUGIURA; Hiroyuki KUMA; Naotaka HAMASAKI

doi:10.1587/transele.E92.C.315

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Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device

Keiji ENPUKU, Yuki SUGIMOTO, Yuya TAMAI, Akira TSUKAMOTO, Takako MIZOGUCHI, Akihiko KANDORI, Naoki USUKI, Hisao KANZAKI, Kohji YOSHINAGA, Yoshinori SUGIURA, Hiroyuki KUMA, Naotaka HAMASAKI

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Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.

Publication: IEICE TRANSACTIONS on Electronics Vol.E92-C No.3 pp.315-322

Publication Date: 2009/03/01

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Online ISSN: 1745-1353

DOI: 10.1587/transele.E92.C.315

Type of Manuscript: Special Section INVITED PAPER (Special Section on Recent Progress in Superconducting Analog Devices and Their Applications)

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Keiji ENPUKU, Yuki SUGIMOTO, Yuya TAMAI, Akira TSUKAMOTO, Takako MIZOGUCHI, Akihiko KANDORI, Naoki USUKI, Hisao KANZAKI, Kohji YOSHINAGA, Yoshinori SUGIURA, Hiroyuki KUMA, Naotaka HAMASAKI, "Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device" in IEICE TRANSACTIONS on Electronics, vol. E92-C, no. 3, pp. 315-322, March 2009, doi: 10.1587/transele.E92.C.315.
Abstract: Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.
URL: https://globals.ieice.org/en_transactions/electronics/10.1587/transele.E92.C.315/_p

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@ARTICLE{e92-c_3_315,
author={Keiji ENPUKU, Yuki SUGIMOTO, Yuya TAMAI, Akira TSUKAMOTO, Takako MIZOGUCHI, Akihiko KANDORI, Naoki USUKI, Hisao KANZAKI, Kohji YOSHINAGA, Yoshinori SUGIURA, Hiroyuki KUMA, Naotaka HAMASAKI, },
journal={IEICE TRANSACTIONS on Electronics},
title={Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device},
year={2009},
volume={E92-C},
number={3},
pages={315-322},
abstract={Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.},
keywords={},
doi={10.1587/transele.E92.C.315},
ISSN={1745-1353},
month={March},}

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TY - JOUR
TI - Liquid-Phase Detection of Biological Targets with Magnetic Marker and Superconducting Quantum Interference Device
T2 - IEICE TRANSACTIONS on Electronics
SP - 315
EP - 322
AU - Keiji ENPUKU
AU - Yuki SUGIMOTO
AU - Yuya TAMAI
AU - Akira TSUKAMOTO
AU - Takako MIZOGUCHI
AU - Akihiko KANDORI
AU - Naoki USUKI
AU - Hisao KANZAKI
AU - Kohji YOSHINAGA
AU - Yoshinori SUGIURA
AU - Hiroyuki KUMA
AU - Naotaka HAMASAKI
PY - 2009
DO - 10.1587/transele.E92.C.315
JO - IEICE TRANSACTIONS on Electronics
SN - 1745-1353
VL - E92-C
IS - 3
JA - IEICE TRANSACTIONS on Electronics
Y1 - March 2009
AB - Liquid-phase detection of biological targets utilizing magnetic marker and superconducting quantum interference device (SQUID) magnetometer is shown. In this method, magnetic markers are coupled to the biological targets, and the binding reaction between them is detected by measuring the magnetic signal from the bound markers. Detection can be done in the liquid phase, i.e., we can detect only the bound markers even in the presence of unbound (free) markers. Since the detection principle is based on the different magnetic properties between the free and bound markers, we clarified the Brownian relaxation of the free markers and the Neel relaxation of the bound markers. Usefulness of the present method is demonstrated from the detection of the biological targets, such as biotin-coated polymer beads, IgE and Candida albicans.
ER -